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In addition, Cyp7a1-overexpressing transgenic mice have been reported to show improved glucose tolerance and reduced G6pc expression under HFD condition 24

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For instance, the substantial amount of lactate produced by glycolysis in tumor cells inhibits the immune-killing functions of natural killer (NK) cells and effector T cells while simultaneously selecting for tumor cells that are more tolerant to acidic conditions

doi: 10.1111/j.1398-9995.2009.02245.x 49 TorresM