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Mutations of Arg347 affect catalysis, while mutations of Leu38 and Ala110 cause structural/functional defects (Montioli et al., 2014)

The equations for calculating the FFLI are being revised as this publication goes to press

Hepatic fat accumulation results from an imbalance between lipid acquisition and lipid disposal, which are regulated through four major pathways: uptake of circulating lipids, de novo lipogenesis (DNL), fatty acid oxidation (FAO), and export of lipids in very low-density lipoproteins (VLDL) (Fig

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Increasing evidence suggests that elevated plasma BCAAs is a risk factor for pancreatic cancer