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The anti-atrophy mechanism of PCHP involved maintaining protein metabolism homeostasis in the gastrocnemius muscle through the IL-6/signal transducer and activator of transcription 3 (STAT3)/cathepsin L (CTSL) and Diacylglycerol kinase (DGK)/the forkhead box O-class (FoxO)/Atrogin1 signaling axis, mediating the ubiquitin-proteasome and autophagy-lysosome systems, and downregulating the accumulation of ceramide via sphingomyelin phosphodiesterase 2 ( 5.1.7 Anti-obesity PCHP could markedly reverse insulin resistance as indicated by a reduction in obesity markers, enhanced leptin and fasting blood glucose levels, and improvements in serum lipid profiles

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10.1128/microbiolspec.gpp3-0039-2018 Microbiol

NAD+ therapy replenishes these energy reserves, helping the body: Recover faster from mental and physical fatigue Regulate stress response hormones Restore motivation and productivity 4

Over the 20-year period, it showed that participants who consumed a diet rich in plants had a 19% reduced risk of developing CVD or dying from CVD compared to participants who consumed animal products (Kim et al., 2019)