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CORRECTION 28 January 2026, 2:10 P.M.: The referenced remternetug trial is not designed to measure drug efficacy and is not sufficient on its own for drug approval, as previously suggested

Cells 183, 10431057.e15

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Furthermore, the adequate activation of alternative pathways should occur along with the additional (direct) beneficial effects on affected targets

However, persistently high-stress levels may trigger ER-mediated apoptosis