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Across hundreds of animal studies, serious adverse effects have not been commonly reported

Among these, GHK upregulated 47 DNA repair genes and modulated pathways relevant to follicle stem cell maintenance (Pickart et al., 2015)

This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]