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For example, in Alzheimers disease, oxidative stress facilitates the hyperphosphorylation of tau protein and enhances beta-amyloid aggregation, promoting neuronal death [235, 236]

Br J Haematol 132:623629 Spada M, Fowler B, Bonetti G, Battistoni G, Baglieri S, Perfetto F, Peduto A, & Ponzone A (1999) Fetal therapy in combined methylmalonic aciduria and homocystinuria