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Results Identification of GPX4 Allosteric Activator In the previous study, we have identified a potential allosteric site in the crystal structure of human GPX4 U46C mutant (hGPX4-C, PDB entry 2OBI

Morris VK, Overman MJ, Lam M, Parseghian CM, Johnson B, Dasari A, Raghav K, Kee BK, Huey R, Wolff RA, Shen JP, Li J, Zorrilla I, Tzeng CD, Tran Cao HS, Chun YS, Newhook TE, Vauthey N, Duose D, Luthra R, Haymaker C, Kopetz S

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Cystic fibrosis NPY was of interest in CF due to its close chromosomal location to CFTR [190]

Liesz et al [57] found that T reg cells antagonize enhanced TNF- and IFN- production, which induce delayed inflammatory brain damage, and that T reg cell-derived secretion of IL-10 is the key mediator of the cerebroprotective effect via suppression of proinflammatory cytokine production