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SKU: 10936714554
Price: 28.84 USD
Availability: InStock
Rating: 4.495900000000001 (13 reviews)

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Description

Bailey LC, Orosz ST

The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

References 1 DelgoffeGM

Resistance to cisplatin, but not oxaliplatin, appears to be partly mediated through loss of function in the MMR proteins (hMLH1, hMLH2, or hMSH6), which recognize platinum-DNA adducts and initiate apoptosis