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This susceptibility arises because germ-free conditions lack microbial metabolites (e.g., SCFAs, bile acid derivatives) that suppress iNKT cell overactivationneonatal exposure to commensal microbes promotes the production of these metabolites, thereby limiting iNKT-mediated inflammatory responses

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Cell 124(4):803814 Custers JH, Harrison SJ, Sela-Buurlage MB, Van Deventer E, Lageweg W, Howe PW et al (2004) Isolation and characterisation of a class of carbohydrate oxidases from higher plants, with a role in active defence