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Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF et al

This upregulation may reflect the cellular attempt to maintain cystine import for glutathione biosynthesis under conditions of heightened oxidative challenge

Involvement of cyclooxygenase and lipoxygenase in ROS production have been demonstrated, but evidence of their participation in redox state and signaling is still scarce [12,13]

As an anaerobic bacterium, it preferentially colonizes hypoxic and necrotic regions of the tumor microenvironment, making it a candidate vehicle for localized drug delivery [56]

Alternatively, changing the environment in which RGCs are transplanted may prevent or modulate these responses